MZT
- Histone concentration regulates the cell cycle and transcription in early development
Summary: Overexpression or knockdown of histones results in delayed or advanced cell cycle slowing and transcriptional activation at the mid-blastula transition, respectively, with differentially expressed genes associated with specific chromatin features.
- The maternal-to-zygotic transition revisited
Summary: The development of animal embryos is initially directed by maternal gene products. This Review discusses the mechanisms that underlie the handover of developmental control to the zygotic genome during the maternal-to-zygotic transition.
- The primary role of zebrafish nanog is in extra-embryonic tissue
Highlighted Article: Detailed analyses of zebrafish nanog mutants, including tissue-specific rescue and chimera analysis, indicate that Nanog is necessary for yolk syncytial layer development but is not directly required for embryonic cell differentiation.