Neuroepithelium
- A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation
Highlighted Article: As neural progenitors mature from forebrain neurectodermal cells to neuroepithelial cells, the mitochondrial landscape, metabolic components and functional ability to employ glycolysis transition to favor oxidative phosphorylation.
- Basal epithelial tissue folding is mediated by differential regulation of microtubules
Summary: Examination of cell shape changes during zebrafish neuroepithelium tissue folding reveals that Wnt5b specifically regulates basal anisotropic cell shape via a microtubule-dependent mechanism, likely involving JNK signaling.
- A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis in Drosophila melanogaster
Highlighted Article: Two types of neural stem cell, with distinct proliferation modes, act side by side to generate the Drosophila optic lobe, challenging current dogma that they act sequentially.
- Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal
Summary: The transcription factor chinmo acts as a master gene of neural stem cell self-renewal in the different regions of the developing Drosophila brain, where it is controlled by distinct regulatory strategies.
- Making sense out of spinal cord somatosensory development
Summary: This review discusses the mechanisms that generate neuronal diversity in the spinal cord, highlighting how different developmental populations produce neurons with distinct somatosensory functions.