Neuronal migration
- Endogenous erythropoietin signaling regulates migration and laminar positioning of upper-layer neurons in the developing neocortex
Highlighted Article: Experimental deregulation of erythropoietin signaling results in an aberrant migration and a permanent neuronal mispositioning, leading to abnormal formation of neuronal networks and sensory behavioral deficits later in life.
- AMP-activated protein kinase regulates cytoplasmic dynein behavior and contributes to neuronal migration in the developing neocortex
Summary: Knockdown and overexpression studies reveal that AMPK associates with dynein, phosphorylates dynein intermediate chain at Ser81, regulates cytoplasmic dynein behavior and drives nuclear migration in migratory neurons of the developing neocortex.
- Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating mouse neurons
Summary: Maintaining actin dynamics is crucial for cell motility. Post-transcriptional regulation plays a pivotal role in supporting actin dynamics during neuronal migration.
- JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons
Summary: Loss of JNK signaling causes cortical interneurons to disperse from migratory streams, prematurely enter the cortical plate and deposit abnormally in the cortical wall.
- Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
Summary: This Review discusses the mechanisms that regulate neuronal migration and associated disorders, with particular focus on appropriate in vivo and in vitro model systems.
- The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis
Summary: The C. elegans cell polarity protein VANG-1 tempers Wnt-mediated neuronal migration by recycling Frizzled receptors from the neuronal membrane.
- The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons
Summary: A knockdown study of lysophosphatidic acid receptor 4 in the developing mouse neocortex reveals that it regulates bipolar morphology and radial migration of newborn neurons through F-actin reorganization.
- Nesprins and opposing microtubule motors generate a point force that drives directional nuclear motion in migrating neurons
Highlighted Article: During migration of mouse cerebellar neurons, microtubules dynamically bind to nesprins in the nuclear envelope via kinesin-1 and dynein, and induce sharpening, rotation and translocation of the nucleus independently of actin.
- Crucial roles of the Arp2/3 complex during mammalian corticogenesis
Summary: During mouse cortical development, the Arp2/3 actin branching complex regulates process formation and the maintenance of radial glial cell polarity, as well as affecting neuronal migration.
- Reelin and cofilin cooperate during the migration of cortical neurons: a quantitative morphological analysis
Summary: In utero electroporation coupled with real-time imaging reveals that actin cytoskeleton dynamics during neuronal migration are controlled by the cooperation of reelin and cofilin.