Neuronal migration
- Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
Summary: This Review discusses the mechanisms that regulate neuronal migration and associated disorders, with particular focus on appropriate in vivo and in vitro model systems.
- The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis
Summary: The C. elegans cell polarity protein VANG-1 tempers Wnt-mediated neuronal migration by recycling Frizzled receptors from the neuronal membrane.
- The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons
Summary: A knockdown study of lysophosphatidic acid receptor 4 in the developing mouse neocortex reveals that it regulates bipolar morphology and radial migration of newborn neurons through F-actin reorganization.
- Nesprins and opposing microtubule motors generate a point force that drives directional nuclear motion in migrating neurons
Highlighted Article: During migration of mouse cerebellar neurons, microtubules dynamically bind to nesprins in the nuclear envelope via kinesin-1 and dynein, and induce sharpening, rotation and translocation of the nucleus independently of actin.
- Crucial roles of the Arp2/3 complex during mammalian corticogenesis
Summary: During mouse cortical development, the Arp2/3 actin branching complex regulates process formation and the maintenance of radial glial cell polarity, as well as affecting neuronal migration.
- Reelin and cofilin cooperate during the migration of cortical neurons: a quantitative morphological analysis
Summary: In utero electroporation coupled with real-time imaging reveals that actin cytoskeleton dynamics during neuronal migration are controlled by the cooperation of reelin and cofilin.
- Inhibitory neuron migration and IPL formation in the developing zebrafish retina
Highlighted article: The quantification of cellular behaviour in real time provides new insights into interneuron migration and inner plexiform layer formation during the lamination of the zebrafish retina.