Optic cup
- Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling
Summary: Cross-subclass interaction of EphB2 with ephrin A5 functions upstream of JNK signaling to maintain an adequate pool of progenitor cells to ensure proper closure of the optic fissure.
- Wnt ligands from the embryonic surface ectoderm regulate ‘bimetallic strip’ optic cup morphogenesis in mouse
Summary: During optic cup morphogenesis, Wnt ligands expressed in the surface ectoderm control cell proliferation in the retinal pigmented epithelium, and thus influence bending of the neural retina.