Otx2
- Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina
Summary: Retinal cells use transcription factors with different expression patterns and cis-regulatory modules with different chromatin configurations to regulate the cell type- and stage-specific expression of Otx2 precisely.
- Phosphorylation states change Otx2 activity for cell proliferation and patterning in the Xenopus embryo
Summary: Repressor and activator activities of Otx2 are regulated by phosphorylation, which may coordinate cell proliferation and differentiation in the neuroectoderm and eye formation in Xenopus.
- ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network
Summary: Surveying the binding profiles of the key transcription factors ZIC2, OTX2, SOX2, POU5F1 and POU3F1 in mouse epiblast stem cells reveals distinct ZIC2-OTX2-centered gene regulation from that in embryonic stem cells.