Parvalbumin
- Cortical interneuron development: a tale of time and space
Summary: This Review examines new insights into cortical GABAergic interneuron subtype specification, focussing on spatial, temporal and genetic mechanisms regulating cell fate decisions in the mouse medial ganglionic eminence.
- Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons
Summary: The regulation of somatostatin (SST) and parvalbumin (PV) mouse cortical interneurons is mediated by Coup-TF1- and Coup-TF2-driven Sox6 expression, identifying a transcriptional pathway that controls SST-PV fate.
- Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells
Summary: Mimicking development, production of parvalbumin versus somatostatin cortical interneurons from embryonic stem cells can be controlled just by modulating culture duration and exposure to sonic hedgehog.