Pax6
- Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development
Summary: In the developing retinal pigmented epithelium (RPE), Pax6 inhibits Sox9 expression and thereby regulates RPE-choroid differentiation. Their mutation causes choroid pathology and implicates novel secreted factors as involved in blinding diseases.
- Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium
Highlighted Article: Loss of the transcription factor Ey/Pax6 leads to failure of the morphogenetic furrow to initiate and pattern the Drosophila retina, providing an unexpected explanation for why eyeless mutants lack eyes.
- Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain
Highlighted Article: Pax6 promotes neuronal differentiation in the developing chick and mouse telencephalon via Notch inhibition, whereas its stage-specific function in RGC maintenance in the VZ is unique to mammalian neocortical progenitors.
- Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye
Highlighted Article: The molecular events underlying the eye-to-wing transdetermination described by Hadorn in 1968 reveal the roles of Pax6 and PcG proteins.