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Pax6

  • RESEARCH ARTICLE
    The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network
    Timothy Grocott, Estefania Lozano-Velasco, Gi Fay Mok, Andrea E. Münsterberg
    Development 2020 147: dev185827 doi: 10.1242/dev.185827 Published 23 December 2020

    Highlighted Article: Pax6 can induce ectopic eye development in vivo, while retinal organoids can self-organise in vitro. We identify a Pax6 Turing network that could explain both phenomena.

  • RESEARCH ARTICLE
    The role of the diencephalon in the guidance of thalamocortical axons in mice
    Idoia Quintana-Urzainqui, Pablo Hernández-Malmierca, James M. Clegg, Ziwen Li, Zrinko Kozić, David J. Price
    Development 2020 147: dev184523 doi: 10.1242/dev.184523 Published 26 June 2020

    Summary: The diencephalon plays a role in the correct organization of thalamocortical axons. The thalamic environment is instructive for their correct medial-lateral position, while prethalamic pioneer axons help to avoid premature fasciculation.

  • RESEARCH ARTICLE
    Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development
    Yamit Cohen-Tayar, Hadar Cohen, Yulia Mitiagin, Zohar Abravanel, Carmit Levy, Masha Idelson, Benjamin Reubinoff, Shalev Itzkovitz, Shaul Raviv, Klaus H. Kaestner, Pablo Blinder, Ran Elkon, Ruth Ashery-Padan
    Development 2018 145: dev163691 doi: 10.1242/dev.163691 Published 9 August 2018

    Summary: In the developing retinal pigmented epithelium (RPE), Pax6 inhibits Sox9 expression and thereby regulates RPE-choroid differentiation. Their mutation causes choroid pathology and implicates novel secreted factors as involved in blinding diseases.

  • RESEARCH ARTICLE
    Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium
    Luke R. Baker, Bonnie M. Weasner, Athena Nagel, Sarah D. Neuman, Arash Bashirullah, Justin P. Kumar
    Development 2018 145: dev163329 doi: 10.1242/dev.163329 Published 2 August 2018

    Highlighted Article: Loss of the transcription factor Ey/Pax6 leads to failure of the morphogenetic furrow to initiate and pattern the Drosophila retina, providing an unexpected explanation for why eyeless mutants lack eyes.

  • RESEARCH ARTICLE
    Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain
    Wataru Yamashita, Masanori Takahashi, Takako Kikkawa, Hitoshi Gotoh, Noriko Osumi, Katsuhiko Ono, Tadashi Nomura
    Development 2018 145: dev159764 doi: 10.1242/dev.159764 Published 16 April 2018

    Highlighted Article: Pax6 promotes neuronal differentiation in the developing chick and mouse telencephalon via Notch inhibition, whereas its stage-specific function in RGC maintenance in the VZ is unique to mammalian neocortical progenitors.

  • RESEARCH ARTICLE
    Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye
    Jinjin Zhu, Alison J. Ordway, Lena Weber, Kasun Buddika, Justin P. Kumar
    Development 2018 145: dev160754 doi: 10.1242/dev.160754 Published 4 April 2018

    Highlighted Article: The molecular events underlying the eye-to-wing transdetermination described by Hadorn in 1968 reveal the roles of Pax6 and PcG proteins.

  • REVIEW
    The cellular and molecular mechanisms of vertebrate lens development
    Aleš Cvekl, Ruth Ashery-Padan
    Development 2014 141: 4432-4447; doi: 10.1242/dev.107953
  • RESEARCH ARTICLES
    Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord
    Xiaosu Li, Zhidong Liu, Mengsheng Qiu, Zhengang Yang
    Development 2014 141: 2875-2884; doi: 10.1242/dev.105387
  • RESEARCH ARTICLES
    Stage-dependent requirement of neuroretinal Pax6 for lens and retina development
    Lucie Klimova, Zbynek Kozmik
    Development 2014 141: 1292-1302; doi: 10.1242/dev.098822
  • STEM CELLS AND REGENERATION
    Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb
    Zsuzsa Agoston, Peer Heine, Monika S. Brill, Britta Moyo Grebbin, Ann-Christin Hau, Wiebke Kallenborn-Gerhardt, Jasmine Schramm, Magdalena Götz, Dorothea Schulte
    Development 2014 141: 28-38; doi: 10.1242/dev.097295

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