Schmidtea mediterranea
- FOX and ETS family transcription factors regulate the pigment cell lineage in planarians
Summary: Identification of the dendritic and punctate classes of marker and of foxF-1, ets-1 and fgfrL-1 as novel specification and maintenance regulators provides insight into mechanisms of pigment cell development and regeneration in adult Schmidtea mediterranea.
- Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians
Highlighted Article: snail-1, snail-2 and zeb-1 control precise homing of stem cells and their progeny to wound sites, whereas the polarity determinant notum controls migration in the absence of wounding to maintain anterior tissue homeostasis.
- The miR-124 family of microRNAs is crucial for regeneration of the brain and visual system in the planarian Schmidtea mediterranea
Summary: miR-124 is required during de novo regeneration of the cephalic ganglion and visual system in planarians, as well as in slit-1 expression in the midline of anterior regenerating tissue via canonical Notch signaling.
- The EGFR signaling pathway controls gut progenitor differentiation during planarian regeneration and homeostasis
Summary: EGFR signaling promotes the differentiation of stem cell-derived progenitors into mature gut cells during both normal homeostasis and regeneration of the planarian Schmidtea mediterranea.
- JNK signalling is necessary for a Wnt- and stem cell-dependent regeneration programme
Summary: The conserved JNK signalling pathway promotes Wnt signalling in stem cells to allow the regeneration of posterior structures in injured flatworms.