Segmentation
- Arthropod segmentation
Summary: This Review describes the regulation and evolution of segment patterning in arthropods, covering the experimental discoveries and conceptual advances of the past 15 years.
- Shifting roles of Drosophila pair-rule gene orthologs: segmental expression and function in the milkweed bug Oncopeltus fasciatus
Summary: Despite the broad conservation of segmentation in insects, the regulatory genes underlying this process in Drosophila have different roles in the hemipteran Oncopeltus fasciatus.
- Tfap2a is a novel gatekeeper of nephron differentiation during kidney development
Summary: tfap2a functions in distal nephron development to control the progression of cells to a fully differentiated state. This fundamentally deepens our knowledge about the genetic control of kidney development.
- Multi-sample SPIM image acquisition, processing and analysis of vascular growth in zebrafish
Summary: A novel dedicated multi-sample light sheet imaging, processing and analysis platform is presented, and its value in diverse quantitative long-term imaging studies, such as vascular growth in zebrafish, is demonstrated.
- Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors
Highlighted Article: Caudal, Dichaete and Odd-paired are likely to regulate pair-rule gene expression similarly in Drosophila and Tribolium, providing a simple mechanism for the evolutionary transition between short-germ and long-germ segmentation modes.
- Conservation and variation in pair-rule gene expression and function in the intermediate-germ beetle Dermestes maculatus
Summary: Expression and functional studies in hide beetles suggest independent roles for pair-rule genes in elongation and segmentation of sequentially segmenting insects, and rewiring of a subset of these regulatory genes.
- Dynamics of growth zone patterning in the milkweed bug Oncopeltus fasciatus
Summary: A detailed analysis of posterior segment addition in an insect reveals that the growth zone is divided into two functional domains responsible for growth and differentiation.
- Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish
Summary: The analysis of zebrafish quadruple Mesp mutants identifies conserved and species-specific mechanisms by which the temporal periodicity of the somitogenesis clock is interpreted.
- The Wnt and Delta-Notch signalling pathways interact to direct pair-rule gene expression via caudal during segment addition in the spider Parasteatoda tepidariorum
Summary: The sequential addition of posterior segments in the spider is controlled by Delta/Notch-mediated regulation of Wnt signalling, and by a downstream gene regulatory network, including pair-rule genes.
- Reiterative expression of pax1 directs pharyngeal pouch segmentation in medaka
Summary: Medaka Pax1 plays a key role in generating the primary pattern for segmentation in the pharyngeal endoderm by regulating the expression of Tbx1 and Fgf3.