Segmentation
- The second pharyngeal pouch is generated by dynamic remodeling of endodermal epithelium in zebrafish
Summary: Live-imaging and cell-tracing experiments demonstrate that dynamic epithelial remodeling fuses the anterior and posterior pharyngeal pouches, which are generated independently, into a seamless array of pouches in zebrafish embryos.
- EPySeg: a coding-free solution for automated segmentation of epithelia using deep learning
Summary: EPySeg is easy-to-use open-source software that applies deep-learning technology for segmentation of membrane-labelled epithelial tissues, either locally or in the cloud.
- Kctd15 regulates nephron segment development by repressing Tfap2a activity
Summary: kctd15 paralogs regulate nephron segment commitment and differentiation through repressor-mediated genetic feedback with tfap2a. This fundamentally deepens our knowledge about the genetic control of kidney development.
- Arthropod segmentation
Summary: This Review describes the regulation and evolution of segment patterning in arthropods, covering the experimental discoveries and conceptual advances of the past 15 years.
- Shifting roles of Drosophila pair-rule gene orthologs: segmental expression and function in the milkweed bug Oncopeltus fasciatus
Summary: Despite the broad conservation of segmentation in insects, the regulatory genes underlying this process in Drosophila have different roles in the hemipteran Oncopeltus fasciatus.
- Tfap2a is a novel gatekeeper of nephron differentiation during kidney development
Summary: tfap2a functions in distal nephron development to control the progression of cells to a fully differentiated state. This fundamentally deepens our knowledge about the genetic control of kidney development.
- Multi-sample SPIM image acquisition, processing and analysis of vascular growth in zebrafish
Summary: A novel dedicated multi-sample light sheet imaging, processing and analysis platform is presented, and its value in diverse quantitative long-term imaging studies, such as vascular growth in zebrafish, is demonstrated.
- Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors
Highlighted Article: Caudal, Dichaete and Odd-paired are likely to regulate pair-rule gene expression similarly in Drosophila and Tribolium, providing a simple mechanism for the evolutionary transition between short-germ and long-germ segmentation modes.
- Conservation and variation in pair-rule gene expression and function in the intermediate-germ beetle Dermestes maculatus
Summary: Expression and functional studies in hide beetles suggest independent roles for pair-rule genes in elongation and segmentation of sequentially segmenting insects, and rewiring of a subset of these regulatory genes.
- Dynamics of growth zone patterning in the milkweed bug Oncopeltus fasciatus
Summary: A detailed analysis of posterior segment addition in an insect reveals that the growth zone is divided into two functional domains responsible for growth and differentiation.