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Self-renewal

  • TECHNIQUES AND RESOURCES
    Defined conditions for propagation and manipulation of mouse embryonic stem cells
    Carla Mulas, Tüzer Kalkan, Ferdinand von Meyenn, Harry G. Leitch, Jennifer Nichols, Austin Smith
    Development 2019 146: dev173146 doi: 10.1242/dev.173146 Published 26 March 2019

    Summary: Detailed protocols for the propagation, manipulation and differentiation of mouse embryonic stem cells, with tips for minimising variability and improving the efficiency, reproducibility and reliability of embryonic stem cell culture.

  • REVIEW
    Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
    Kirsten Obernier, Arturo Alvarez-Buylla
    Development 2019 146: dev156059 doi: 10.1242/dev.156059 Published 18 February 2019

    Summary: This Review discusses the identification, regulation and heterogeneity of neural stem cells and examines recent insights into their transcriptomic properties and mechanism of persistence into adulthood.

  • STEM CELLS AND REGENERATION
    Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal
    Caroline Dillard, Karine Narbonne-Reveau, Sophie Foppolo, Elodie Lanet, Cédric Maurange
    Development 2018 145: dev154534 doi: 10.1242/dev.154534 Published 25 January 2018

    Summary: The transcription factor chinmo acts as a master gene of neural stem cell self-renewal in the different regions of the developing Drosophila brain, where it is controlled by distinct regulatory strategies.

  • STEM CELLS AND REGENERATION
    Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors
    Chao Wang, Min Wang, Justine Arrington, Tizhong Shan, Feng Yue, Yaohui Nie, Weiguo Andy Tao, Shihuan Kuang
    Development 2017 144: 235-247; doi: 10.1242/dev.138099

    Summary: The transcription factor Ascl2 is identified as a novel inhibitor of myogenic regulatory factors in mice, acting to inhibit myogenic differentiation and facilitate the generation of postnatal satellite cells.

  • STEM CELLS AND REGENERATION
    DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
    Xing Ma, Yingying Han, Xiaoqing Song, Trieu Do, Zhihao Yang, Jianquan Ni, Ting Xie
    Development 2016 143: 4312-4323; doi: 10.1242/dev.141069

    Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary.

  • STEM CELLS AND REGENERATION
    A role for post-transcriptional control of endoplasmic reticulum dynamics and function in C. elegans germline stem cell maintenance
    Richa Maheshwari, Kumari Pushpa, Kuppuswamy Subramaniam
    Development 2016 143: 3097-3108; doi: 10.1242/dev.134056

    Summary: PUF-8 promotes germline stem cell proliferation by promoting the expression of FARL-11, an ER protein that facilitates the membrane localization of GLP-1 /Notch.

  • STEM CELLS AND REGENERATION
    Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes
    Jun Yu, Xiang Lan, Xia Chen, Chao Yu, Yiwen Xu, Yujuan Liu, Lingna Xu, Heng-Yu Fan, Chao Tong
    Development 2016 143: 2930-2945; doi: 10.1242/dev.134247

    Summary: A large-scale RNAi screen in Drosophila testes reveals that many genes involved in protein synthesis and degradation are required for the homeostasis of germline stem cells and their niches.

  • RESEARCH REPORT
    The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina
    Marine Lacomme, Basile Tarchini, Camille Boudreau-Pinsonneault, Carine Monat, Michel Cayouette
    Development 2016 143: 575-581; doi: 10.1242/dev.129783

    Highlighted article: LGN inactivation in mice disrupts spindle orientation in both the retina and neocortex but leads to very different outcomes with regards to cell fate in each context.

  • REVIEWS
    Intrinsic and extrinsic mechanisms regulating satellite cell function
    Nicolas A. Dumont, Yu Xin Wang, Michael A. Rudnicki
    Development 2015 142: 1572-1581; doi: 10.1242/dev.114223

    Summary: This Review discusses how satellite stem cell behaviour is regulated during regeneration and degeneration by a complex balance between extrinsic cues and intrinsic regulatory mechanisms.

  • STEM CELLS AND REGENERATION
    p53 enables metabolic fitness and self-renewal of nephron progenitor cells
    Yuwen Li, Jiao Liu, Wencheng Li, Aaron Brown, Melody Baddoo, Marilyn Li, Thomas Carroll, Leif Oxburgh, Yumei Feng, Zubaida Saifudeen
    Development 2015 142: 1228-1241; doi: 10.1242/dev.111617

    Highlighted article: Although classically thought to restrain proliferation, p53 promotes self-renewal in nephron progenitors of the mouse kidney and also regulates their metabolic profile.

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