Sex differentiation
- Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish – a novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis
Summary: Genetic analysis in zebrafish shows that estrogens produced by Cyp19a1a induce ovarian differentiation by suppressing Dmrt1 expression; however, they play little role in controlling the subsequent early folliculogenesis.
- Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish
Summary: Zar1 RNA binding protein represses zona pellucida RNA translation during early oogenesis. zar1 deletion mutants show ER stress and apoptosis in oocytes and result in an all-male phenotype.