Six3
- SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression
Summary: Conditional deletion of Sp8, Sp9 and Six3 reveals a regionally specific transcription pathway that selectively drives the generation of striatal DRD2-expressing medium spiny neurons in mouse striatum.
- A key role for foxQ2 in anterior head and central brain patterning in insects
Summary: foxQ2 and six3 form a regulatory module at the top of the gene network governing anterior development of the Tribolium castaneum embryo.
- Six3 dosage mediates the pathogenesis of holoprosencephaly
Summary: Analysis of a hypomorphic Six3 allele reveals that variability in Six3 dosage is sufficient to generate mice exhibiting a spectrum of holoprosencephaly forms in a non-strain-specific manner.
- Neurogenic gene regulatory pathways in the sea urchin embryo
Summary: Molecular screens and knockdown studies reveal that SoxC and Brn1/2/4 function sequentially during neurogenesis in sea urchin embryos and are required for the differentiation of all neurons.