Tbx5
- Regulatory integration of Hox factor activity with T-box factors in limb development
Summary: Genomic analyses in mice reveal integrated actions of hindlimb-restricted transcription factors Tbx4, Hoxc10 and Pitx1, and identify a novel composite T-box–Hox DNA motif that integrates Hox modulation of Tbx-dependent transcription.
- Pitx1 directly modulates the core limb development program to implement hindlimb identity
Summary: A small set of limb type-restricted genes among the broadly conserved Pitx1 gene regulatory network, including components of the chondrogenic program, establishes hindlimb identity in mouse.